What causes the cellular damage which leads to the deposition of proteins in the neurons? Also, how does this disease affects the enzyme/substrate required for dopamine production?
Supp Lester! Cellular damage is caused by the amine-related aldehydes, e.g. 3,4-dihydroxyphenylacetaldehyde (DOPAL), and other aldehyde- and oxidative toxic molecules that failed to be metabolised by the aldehyde dehydrogenase
Hi.
ReplyDeleteWhat causes the cellular damage which leads to the deposition of proteins in the neurons? Also, how does this disease affects the enzyme/substrate required for dopamine production?
Thanks.
Oh! The decrease in the enzyme activity (due to the decrease in substrates) required for dopamine is the cause of the disease.
DeleteSupp Lester! Cellular damage is caused by the amine-related aldehydes, e.g. 3,4-dihydroxyphenylacetaldehyde (DOPAL), and other aldehyde- and oxidative toxic molecules that failed to be metabolised by the aldehyde dehydrogenase
ReplyDeleteNice and neat layout blog you have Daniel and Benjamin!
ReplyDeleteIts nice that fun facts from TEDed is added.
I would just like to know how does Parkinson affect depression, dementia, dystonia, and sleep disturbances?
- Jodie